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CAS No.: 6902-77-8

京尼平 Catalog No. CSN11088

Synonyms: (+)-Genipin;京尼平

Genipin is a naturally occuring cross linking agent found in gardenia fruit with anti-inflammatory and anti-angiogenesis effects.

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生物活性

描述Genipin is an effective cross-linking reagent derived from Gardenia jasminoides Ellis fruits. Genipin at a concentration of 50μM inhibited superoxide-activated, uncoupling protein 2-mediated mitochondrial proton leak in the mitochondria isolated from mouse kidney.^[4] Genipin increased glucose uptake in C₂C₁₂ myotubes in a dose-dependent (1 – 10μM) and time-dependent (0.5 – 2 hours) manner. Also in C₂C₁₂ myotubes, 10 μM of genipin increased the cellular concentrations of adenosine triphosphate and reactive oxygen species within 30 min of incubation.^[5] Intraperitoneal administration of genipin at a dose of 25mg/kg/day for 7 days attenuated depression-like behaviors and normalized reduced hippocampal Bdnf expression in young adult PRS mice.^[3]
作用机制Genipin is a monoterpenoid compound with multiple bioactive properties, such as anti-inflammatory, anti-angiogenic, and anti-depressive activities.^[3]
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4204 mL
- 22.1018 mL
- 44.2036 mL
- 5 mM
- 0.8841 mL
- 4.4204 mL
- 8.8407 mL
- 10 mM
- 0.4420 mL
- 2.2102 mL
- 4.4204 mL

技术信息

CAS号

6902-77-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H14O5

运输

蓝冰

分子量

226.23

别名

(+)-Genipin;京尼平

溶解度

DMSO	95.0 mg/mL (419.9 mM) warming
Water	4.0 mg/mL (17.7 mM) warming

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